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Download e-book for iPad: A calcium-based phantom bursting model for pancreatic islets by Richard Bertram, Arthur Sherman

By Richard Bertram, Arthur Sherman

Insulin-secreting β-cells, positioned in the pancreatic islets of Langerhans, are excitable cells that produce standard bursts of motion potentials whilst inspired by way of glucose. the program has been the focal point of mathematical research for 2 many years, spawning an array of mathematical versions. lately, a brand new category of types has been brought referred to as 'phantom bursters' [Bertram et al. (2000) Biophys. J. seventy nine, 2880-2892], which debts for the big variety of burst frequencies exhibited through islets through the interplay of multiple gradual approach. the following, we describe one implementation of the phantom bursting mechanism within which intracellular Ca2+ controls the oscillations via either direct and oblique detrimental suggestions pathways. We convey how the version dynamics will be understood via an extension of the fast/slow research that's regularly hired for bursting oscillations. From this angle, the version uses a number of levels of freedom to generate the entire diversity of bursting oscillations exhibited via β-cells. The version additionally money owed for quite a lot of experimental phenomena, together with the ever-present triphasic reaction to the step elevation of glucose and responses to perturbations of inner Ca2+ shops. even though it isn't really shortly an entire version of all β-cell homes, it demonstrates the layout rules that we expect will underlie destiny development in β-cell modeling.

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J. Jarvis (Eds), Lecture Notes in Mathematics 1151, Berlin: Springer, pp. 304–316. Roe, M. , M. E. Lancaster, R. J. Mertz, J. F. Worley III and I. D. Dukes (1993). Voltagedependent intracellular calcium release from mouse islets stimulated by glucose. J. Biol. Chem. 268, 9953–9956. Roe, M. , L. H. Philipson, C. J. Frangakis, A. Kuznetsov, R. J. Mertz, M. E. Lancaster, B. Spencer, J. F. Worley III and I. D. Dukes (1994). Defective glucose-dependent endoplasmic reticulum Ca2+ sequestration in diabetic mouse islets of Langerhans.

Am. J. Physiol. 273, C717–C733. Mart´ın, F. and B. Soria (1995). Amino acid-induced [Ca2+ ]i oscillations in single mouse pancreatic islets. J. Physiol. ) 486, 361–371. Matthews, D. , B. A. Naylor, R. G. Jones, G. M. Ward and R. C. Turner (1983). Pulsatile insulin secretion has greater hypoglycemic effect than continuous delivery. Diabetes 32, 617–621. Mears, D. and C. Zimliki (2003). Muscarinic agonists activate Ca2+ store-operated and -independent ionic currents in insulin-secreting HIT-T15 cells and mouse pancreatic β-cells.

J. Physiol. ) 503, 387–398. , V. -O. Berggren, B. E. Corkey and K. Tornheim (1996). Temporal patterns of changes in ATP/ADP ratio, glucose 6-phosphate and cytoplasmic free Ca2+ in glucose-stimulated pancreatic β-cells. Biochem. J. 314, 91–94. 1344 R. Bertram and A. Sherman O’Meara, N. , J. Sturis, J. D. Blackman, M. M. Byrne, J. B. Jaspan, J. R. Thistlethwaite and K. S. Polonsky (1993). Oscillatory insulin secretion after pancreas transplant. Diabetes 42, 855–861. Rinzel, J. (1985). Bursting oscillations in an excitable membrane model, in Ordinary and Partial Differential Equations, B.

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A calcium-based phantom bursting model for pancreatic islets by Richard Bertram, Arthur Sherman

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